Rabbit Anti-IKAROS Polyclonal Antibody

  • Rabbit Anti-IKAROS Polyclonal Antibody

    CatalogueID : bs-8172R

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Target ikaros
Species Cross Reactivity Mus musculus, Rattus norvegicus, Homo sapiens, Gallus gallus
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications IHC-Fr, WB, IP, EIA, IHC, IF
Unit 100 ug Lyophilized
Format 1ug/uL, Two additional vials are included in shipment for reconstitution purposes (double distilled H20 and sterile glycerol). Centrifuge all vials to ensure necessary quantities have settled. Add 50uL of sterile double distilled water to antibody. Mix thoroughly by gently pipetting up and down. Then, add 50uL of sterile glycerol to antibody. Mix well and keep cold., *Please note lyophilized powder is supplied in bovine serum albumin and sodium azide. After reconstitution, final concentration of preservatives are 10ug/uL BSA and 0.1% NaN3
Concentration 1ug/uL
NCBI Gene Aliases IKAROS family zinc finger 1 (Ikaros);, PRO0758;, CLL associated antigen KW 6;, DNA-binding protein Ikaros;, hIk 1;, hIk-1;, IK1;, Ikaros (zinc finger protein);, IKAROS;, Ikaros family zinc finger protein 1;, Ikzf1;, IKZF1_HUMAN;, LYF1;, Lymphoid transcription factor LyF-1;, zinc finger protein subfamily 1A 1;, ZNFN1A1
Description Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs)., Tissue specificity: Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine
Company Bioss
Type Antibody
Immunogen KLH conjugated synthetic peptide derived from human IKAROS
Isotype IgG
Molecular Weight 55-63kDa
Purity Was purified by Protein A and peptide affinity chromatography