Rabbit Anti-FBXL20 Polyclonal Antibody

  • Rabbit Anti-FBXL20 Polyclonal Antibody

    CatalogueID : bs-8473R

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Target Fbxl20
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF, IHC-Fr
Unit 100 ug Lyophilized
Format 1ug/uL, Two additional vials are included in shipment for reconstitution purposes (double distilled H20 and sterile glycerol). Centrifuge all vials to ensure necessary quantities have settled. Add 50uL of sterile double distilled water to antibody. Mix thoroughly by gently pipetting up and down. Then, add 50uL of sterile glycerol to antibody. Mix well and keep cold., *Please note lyophilized powder is supplied in bovine serum albumin and sodium azide. After reconstitution, final concentration of preservatives are 10ug/uL BSA and 0.1% NaN3
Concentration 1ug/uL
NCBI Gene Aliases F box/LRR repeat protein 20;, F box/LRR repeat protein 2 like;, F box/LRR repeat protein 20;, Fbl2;, Fbl20;, F box and leucine rich repeat protein 20;, MGC15482;, SCR;, SCRAPPER
Description FBXL20 is a member of the F-box protein family, which are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. FBXL20 is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. FBXL20 has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. FBXL20 is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check
Company Bioss
Type Antibody
Immunogen KLH conjugated synthetic peptide derived from human FBXL20
Isotype IgG
Molecular Weight 44/48kDa
Purity Was purified by Protein A and peptide affinity chromatography