EBNA-1 Mouse anti-Epstein-Barr Virus Monoclonal (E1-2.5) Antibody

  • EBNA-1 Mouse anti-Epstein-Barr Virus Monoclonal (E1-2.5) Antibody

    CatalogueID : LS-C58268-100

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Target EBNA-1
Species Cross Reactivity Viral (Species unspecified)
Host Species Mus musculus
Target Tag/Conjugate Unconjugated
Applications EIA
Clone E1-2.5
Unit 100 Ķg
Format PBS, pH 7.4, 0.09% sodium azide
Concentration 1 mg/ml
Description Specificity: Recognizes the repetitive Gly-Ala region of EBV (Epstein-Barr Virus) nuclear antigen 1 (EBNA-1), a viral protein expressed consistently by EBV associated malignancies. EBV, also known as HHV-4 (Human herpesvirus 4), is a member of the herpesvirus family and one of the most common infectious viruses known, being responsible for a wide range of illnesses from infectious mononucleosis to nasal-pharyngeal cancer. EBNA-1 is the only viral protein expressed during group 1 latency and mediates the replication and partitioning of the episome during host cell division, binding to a replication origin (oriP) within the viral genome. The Gly-Ala repeat recognized by this antibody, inhibits the host's CD8-restricted cytotoxic T-cell response to infected cells, by impairing antigen processing and MHC class I-restricted antigen presentation. Reported as suitable for use in immunocytochemistry
Cite This Product LifeSpan BioSciences cat# LS-C58268-100 RRID:AB_10558406
Company LifeSpan BioSciences
Type Antibody
Isotype IgG2b
Purity Affinity purified
Clonality Monoclonal