karyopherin alpha 2 Antibody

  • karyopherin alpha 2 Antibody

    from biorbyt
    CatalogueID : orb41245

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Target karyopherin alpha 2
Species Cross Reactivity Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications IF, WB
Target Species Homo sapiens
Unit 100 μl
Concentration 0.71 mg/ml
Description Rabbit polyclonal to karyopherin alpha 2. The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq]
Immunogen karyopherin alpha 2
Product Name Alias anti-QIP2 antibody, anti-RCH1 antibody, anti-IPOA1 antibody, anti-SRP1alpha antibody
Clonality Polyclonal