Human INTERLEUKIN-11

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Species Human
Format Purity: >98% by SDS PAGE
Format: Purified recombinant protein - lyophilised
Target/Molecule Synonym Interleukin 11
Target Tag/Conjugate Unconjugated
Molecule Name INTERLEUKIN-11
References [1] Ishii. T. Zhao. Y. Shi. J. Sozer. S. Hoffman. R. and Xu. M. et al.
T cells from patients with polycythemia vera elaborate growth factors which contribute to endogenous erythroid and megakaryocyte colony formation
[2] Paiva. P. Salamonsen. L. A. Manuelpillai. U. Walker. C. Tapia. A. Wallace. E. M. and Dimitriadis. E.
Interleukin-11 promotes migration. but not proliferation. of human trophoblast cells. implying a role in placentation
[3] Pascal. T. Debacq-Chainiaux. F. Boilan. E. Ninane. N. Raes. M. and Toussaint. O.
Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol
[4] Nakayama. T. Yoshizaki. A. Izumida. S. Suehiro. T. Miura. S. Uemura. T. Yakata. Y. Shichijo. K. Yamashita. S. and Sekin. I.
Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells
[5] Bhatia. M. Davenport. V. and Cairo. M. S. et al.
The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors. lymphoma. acute myeloid leukemia and bone marrow failure syndromes
Applications Functional Studies
Source/Expression System Recombinant
Category Protein
Accession Number Accession Number: NP_000632.1
Original Item Name RECOMBINANT HUMAN INTERLEUKIN-11
Unit 0.01 mg
Description Summary: The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes. all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Sequence Length (aa): 199 OMIM: NCBI [ 147681] Applications Tested: FN Cross-Reactivity: Human Storage: Prior to reconstitution store at +4C. Following reconstitution store at -20C. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Stability: 3 months from date of reconstitution. Specificity: IL-11 Specificity: IL-11 Approx. Protein Conc: 100 ng/ul Preservative Stabilisers: None presentReconstitution: Reconstitute with 0.1 ml distilled water Product ID: 79032