beta-Amyloid, aa 1-40

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Target Tag/Conjugate Unconjugated
Target/Molecule Synonym Amyloid beta (A4) protein [Mus musculus], Amyloid protein, APP
Format Purity: > 95%
References [1] Steinkasserer A.. Estaller C.. Weiss E.. Sim R.B.. Day A.J.
Complete nucleotide and deduced amino acid sequence of human beta 2-glycoprotein I.
[2] Kristensen T.. Schousboe I.. Boel E.. Mulvihill E.M.. Hansen R.R.. Moeller K.B.. Moeller N.P.H.. Sottrup-Jensen L.
Molecular cloning and mammalian expression of human beta 2-glycoprotein I cDNA.
[3] Mehdi H.. Nunn M.. Steel D.M.. Whitehead A.S.. Perez M.. Walker L.. Peeples M.E.
Nucleotide sequence and expression of the human gene encoding apolipoprotein H (beta 2-glycoprotein I).
[4] Day J.R.. O'Hara P.J.. Grant F.J.. Lofton-Day C.E.. Berkaw M.N.. Werner P.. Arnaud P.
Molecular cloning and sequence analysis of the cDNA encoding human apolipoprotein H (beta 2-glycoprotein I).
[5] Matsuura E.. Igarashi M.. Igarashi Y.. Nagae H.. Ichikawa K.. Yasuda T.. Koike T.
Molecular definition of human beta 2-glycoprotein I (beta 2-GPI) by cDNA cloning and inter-species differences of beta 2-GPI in alternation of anticardiolipin binding.
[6] Okkels H.. Rasmussen T.E.. Sanghera D.K.. Kamboh M.I.. Kristensen T.
Structure of the human beta2-glycoprotein I (apolipoprotein H) gene.
[7] Rieder M.J.. Carrington D.P.. da Ponte S.H.. Hastings N.C.. Ahearn M.O.. Kuldanek S.A.. Rajkumar N.. Toth E.J.. Yi Q.. Nickerson D.A.. et al.
SeattleSNPs. NHLBI HL66682 program for genomic applications. UW-FHCRC. Seattle. WA (URL: http://pga.gs.washington.edu).
[8] Strausberg R.L.. Feingold E.A.. Grouse L.H.. Derge J.G.. Klausner R.D.. Collins F.S.. Wagner L.. Shenmen C.M.. Schuler G.D.. Altschul S.F.. et al.
Generation and initial analysis of more than 15.000 full-length human and mouse cDNA sequences.
[9] Lozier J.. Takahashi N.. Putnam F.W.
Complete amino acid sequence of human plasma beta 2-glycoprotein I.
[10] Matsuura E.. Igarashi Y.. Fujimoto M.. Ichikawa K.. Suzuki T.. Sumida T.. Yasuda T.. Koike T.
Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor.
Original Item Name beta-Amyloid (1-40)
Molecule Name beta-Amyloid, aa 1-40
Category Peptide
Accession Number NCBI Accession Number: NP_031497.2
Swiss Protein Accession Number: O88868
Unit 0.5 mg
Description beta-Amyloid peptide (beta-APP) is a 40-residue peptide implicated in the pathogenesis of Alzheimers disease (AD) and aged Down's Syndrome (which is promoted by the acquisition of an additional copy of chromosome 21). The peptide is a proteolytic product of the much larger amyloid precursor protein (APP) encoded by a gene on chromosome 21. The peptide comprises a large extracellular N-terminal domain. and a short hydrophobic membrane-spanning domain. followed by a short C-terminal region. beta-APP both precedes and forms part of the transmembrane region.N/A Entry Name: O88868_MOUSE Sequence Position 1: 1 Sequence Position 2: 40 Length (aa): 695 MW: 1951 KEGG pathway: Alzheimer's disease 05010KEGG pathway: Neurodegenerative Disorders 01510 Storage: 4°C for short term (weeks) and -20°C for long term. Stability: 6-12 months at -20°C. Sequence (One Letter Code): DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVSequence: {ASP} {ALA} {GLU} {PHE} {ARG} {HIS} {ASP} {SER} {GLY} {TYR} {GLU} {VAL} {HIS} {HIS} {GLN} {LYS} {LEU} {VAL} {PHE} {PHE} {ALA} {GLU} {ASP} {VAL} {GLY} {SER} {ASN} {LYS} {GLY} {ALA} {ILE} {ILE} {GLY} {LEU} {MET} {VAL} {GLY} {GLY} {VAL} {VAL} Formula: C194H295N53O58S1 Solubility: InSoluble in water. May be dissolved in any buffer with pH>9.