Human Mutant p53 Protein

  • Human Mutant p53 Protein

    CatalogueID : GWB-F084CB

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Target Tag/Conjugate Unconjugated
Target/Molecule Synonym MBP1, MBP1, p53M, Q96TF5_HUMAN
Format Purity: Greater than 90% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by reducing and non-reducing SDS-PAGE coomassie blue gel.
Format: 100 ug/ml in 50 mM Tris-Acetate. pH7.5. 1 mM EDTA. 20% Glycerol without BSA and Sodium Azide.
Endotoxin: Less than 0.1 ng/ug (IEU/ug) of Human Mutant p53.
Species Human
Molecule Name Mutant p53 Protein
Original Item Name Mutant p53 Protein Human
Category Protein
References [1] Tanaka.S. Sugimachi.K. and Sugimachi.K. et al.
Human mutant p53 binding protein (MBP1)
[2] Tanka.S. et al.
Direct Submission
[3] Tanaka S. Sugimachi K. Sugimachi K.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[4] Tanka S.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Source/Expression System E. coli
Unit 0.002 mg
Description p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth. replication. and apoptosis. It binds to mdm2. SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors. including breast. ovarian. bladder. colon. lung. and melanoma.Recombinant Mutant p53 shows a band at 81kDa on SDS-PAGE commassie blue stained gel. Recombinant Mutant p53 purified by proprietary chromatographic techniques.N/A Sequence Length (aa): 443 MW: 49421Human Storage: 4°C for short term (weeks) and -20°C for long term. Avoid frequent freeze and thaw. Stability: 5 years at -20°C. Aggregates: Less than 1% as determined by coomassie blue SDS-PAGE gel analysis. Product ID: 45595