Human Proguanylin

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Target/Molecule Synonym Guanylate cyclase activator 2A, Guanylin, Guanylate cyclase activator 2A, Guanylate cyclase-activating protein 1, Gap-I, GUCA2A, Proguanylin, GUCA2
Target Tag/Conjugate Unconjugated
Format Purity: Purity of recombinant human proguanylin is Greater than 95% (SDS-PAGE analyzed).
Format: Sterile filtered and lyophilized from 0.5 mg/ml in deionized H2O.
Species Human
Molecule Name Proguanylin
References [1] Mishra. G. R. Suresh. M. Kumaran. K. Kannabiran. N. Suresh. S. Bala. P. Shivakumar. K. Anuradha. N. Reddy. R. Raghavan. T. M. et al.
Human protein reference database--2006 update
[2] Albano. F. de Marco. G. Canani. R. B. Cirillo. P. Buccigrossi. V. Giannella. R. A. and Guarino. A.
Guanylin and E. coli heat-stable enterotoxin induce chloride secretion through direct interaction with basolateral compartment of rat and human colonic cells
[3] Sindic. A. Hirsch. J. R. Velic. A. Piechota. H. and Schlatter. E. et al.
Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts
[4] Kulaksiz. H. Schlenker. T. Rost. D. Stiehl. A. Volkmann. M. Lehnert. T. Cetin. Y. and Stremmel. W.
Guanylin regulates chloride secretion in the human gallbladder via the bile fluid
[5] Peri. S. Navarro. J. D. Kristiansen. T. Z. Amanchy. R. Surendranath. V. Muthusamy. B. Gandhi. T. K. Chandrika. K. N. et al.
Human protein reference database as a discovery resource for proteomics
[6] Wiegand R. C. Kato J. Huang M. D. Fok K. F. Kachur J. F. Currie M. G.
Human guanylin: cDNA isolation. structure. and activity.
[7] de Sauvage F. J. Keshav S. Kuang W. J. Gillett N. Henzel W. Goeddel D. V.
Precursor structure. expression. and tissue distribution of human guanylin.
[8] Hill O. Kuhn M. Zucht H. -D. Cetin Y. Kulaksiz H. Adermann K. Klock G. Rechkemmer G. Forssmann W. -G. Maegert H. -J. et al.
Analysis of the human guanylin gene and the processing and cellular localization of the peptide.
[9] Kuhn M. Raida M. Adermann K. Schulz-Knappe P. Gerzer R. Heim J. -M. Forssmann W. -G.
The circulating bioactive form of human guanylin is a high molecular weight peptide (10. 3 kDa).
[10] Skelton N. J. Garcia K. C. Goeddel D. V. Quan C. Burnier J. P.
Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.
Original Item Name Proguanylin Human
Source/Expression System E. coli
Accession Number Accession Number: NP_291031.2
Sp Accession Number: Q02747
Category Protein
Unit 0.002 mg
Description Function: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.Subcellular Location: Secreted protein.Tissue Specificity: Highly expressed in ileum and colon. Found in plasma.Similarity: Belongs to the guanylin family. Chromosome Location: 1p35-p34 Sequence Length (aa): 115 MW: 12448 OMIM: 139392; gene. [ NCBI / EBI] Testing Protocols: Western Blot Cross-Reactivity: Human Storage: 4°C for short term (weeks) and -20°C for long term. Avoid frequent freeze and thaw. Stability: 5 years at -20°C. Specificity: The recombinant human proguanylin is 100% homologous with the human proguanylin. Specificity: The recombinant human proguanylin is 100% homologous with the human proguanylin. Reconstitution: Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely. Protein Family: Belongs to the guanylin family. Product ID: 45479