Human NT‑3, research grade

  • Human NT‑3, research grade

    CatalogueID : 130-093-973

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Format Research Grade
Purified
Source/Expression System E. coli
Original Item Name Human NT-3, research grade
Category Premium and research grade
Molecule Name neurotrophin 3
Target/Molecule Descriptor Research Grade
Species human
Keywords NT3
Unit 10 µg
Description NT-3 stands for neurotrophin 3, also termed hippocampus-derived neurotrophic factor (HDNF). Human NT-3 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.:Human NT-3 can be used for a variety of applications, including::• In vitro stimulation of endothelial cell survival. :• Proangiogenic capacity of recombinant NT-3 in vitro. :• Survival and differentiation factor in neuronal cell culture. :• Trk signaling. :• Stimulation of axon outgrowth in vitro.; NT-3 is a member of the neurotrophin family. It shares high structural homology to nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 4 (NT-4) but they all operate via different high-affinity membrane receptors and differ in target specificity. Expression of NT-3 has been detected in neurons of the central nervous system like the hippocampus and cerebellum. Furthermore it is expressed in muscles. NT-3 promotes the survival and differentiation of existing neurons and supports the growth and differentiation of new nerve and glial cells. It has been shown to bind and activate the TrkC tyrosine receptor kinase. The activities of NT-3 and BDNF are additive in some systems. The amino acid sequence of human and mouse NT-3 is identical