Human DEP1, aa 1024-1306

  • Human DEP1, aa 1024-1306

    CatalogueID : 10-054-165004

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Target/Molecule Synonym Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen), Receptor-type tyrosine-protein phosphatase et, EC 3.1.3.48, Protein-tyrosine phosphatase eta, R-PTP-eta, HPTP eta, Protein-tyrosine phosphatase receptor type J, Density-enhanced phosphatase 1, DEP-1, CD148 antigen, DEP1
Target Tag/Conjugate Unconjugated
Format Purity: > 95% by SDS-PAGE
Format: 25 mM Tris-HCl. pH 8.0. 75 mM NaCl. 0.05% Tween-20. 50% glycerol. 2 mM EDTA. 1 mM DTT. 10 mM glutathione.
Species Human
Accession Number NCBI Accession Number: Q12913
Swiss Protein Accession Number: Q12913
Source/Expression System E. coli
Molecule Name DEP1, aa 1024-1306
Original Item Name DEP1 (1024-1306) HUMAN
EC Number EC 3.1.3.48
Category Protein
Unit 0.02 mg
Description Protein tyrosine phosphatase. (density-enhanced phosphatase-1. PTP-eta.CD148). Catalytic domain. (a.a. 1024-1306) (Gene bank accession no. NM_U10886) with NterminalGST tag. MW=58.9 kDa. expressed in an E.coli expression system.Function: May contribute to the mechanism of contact inhibition of cell growth.Catalytic Activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.Subcellular Location: Membrane; single-pass type I membrane protein.Ptm: N- and O-glycosylated.Disease: Defects in PTPRJ are found in cancers of colon. lung. and breast.Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.Similarity: Contains 9 fibronectin type-III domains.Similarity: Contains 1 tyrosine-protein phosphatase domain. Entry Name: PTPRJ_HUMAN Sequence Position 1: 1024 Sequence Position 2: 1306 Length (aa): 1337 MW: 145927 OMIM: 600925; gene. [ NCBI / EBI] Storage: >6 months at -80°C Specific Activity: 114 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphateper minute at pH 7.4 and 30?C. Assay buffer: 50 mM HEPES. pH 7.4. 2 mM EDTA. 3mM DTT. 100 mM NaCl. 50 mM Pnpp. and 0.5 ug/ml enzyme. Application: Useful for the study of enzyme kinetics. regulation. and todephosphorylate target substrates.