GM-CSF, Rat, Recombinant

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Molecule Name GM-CSF
Source/Expression System Hematopoietic stem & progenitor cells
Original Item Name GM-CSF, Rat, Recombinant
Host E. coli
Category Cytokines
Unit 5 µg
Description Granulocyte-macrophage colony-stimulating factorGranulocyte-macrophage colony-stimulating factor (GM-CSF) is a growth factor for granulocyte-macrophage progenitors, as well as erythroid, megakaryocyte and eosinophil progenitors. GM-CSF is produced by cell types such as activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts in response to cytokine or immune and inflammatory stimuli. GM-CSF can also activate effector functions of mature granulocytes, monocytes, macrophages and eosinophils. It is also thought that GM-CSF has a functional role on nonhematopoietic cells, and can stimulate the proliferation of tumor cells, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines. Recombinant rat GM-CSF preparation contains a mixture of the 127 and 128 amino acid residue methionyl forms of rat GM-CSF. The mature rat GM-CSF has a calculated mass of 14.7 kDa. Recombinant rat GM-CSF is reactive with mouse cells