Human THROMBOPOIETIN

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Target/Molecule Synonym Thrombopoietin, TPO
Target Tag/Conjugate Unconjugated
Species Human
Format Purity: >98% by SDS PAGE and HPLC analysis
Format: Purified recombinant protein expressed in E. coli - lyophilised
Accession Number Accession Number: NP_000451.1
Original Item Name RECOMBINANT HUMAN THROMBOPOIETIN
Applications Functional Studies
Molecule Name THROMBOPOIETIN
References [1] Steinberg. O. Gilad. G. Dgany. O. Krasnov. T. Zoldan. M. Laor. R. Kapelushnik. J. Gabriel. H. Churi. C. Stein. J. Yaniv. I. and. et al.
Congenital amegakaryocytic thrombocytopenia-3 novel c-MPL mutations and their phenotypic correlations
[2] Kanayasu-Toyoda. T. Ishii-Watabe. A. Suzuki. T. Oshizawa. T. and Yamaguchi. T.
A new role of thrombopoietin enhancing ex vivo expansion of endothelial precursor cells derived from AC133-positive cells
[3] Wasiluk. A. Mantur. M. Kemona-Chetnik. I. Szczepanski. M. Warda. J. and Bochenko-Luczynska. J.
Does prematurity affect thrombocytopoiesis?
[4] Tong. W. Ibarra. Y. M. and Lodish. H. F. et al.
Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal
[5] Migliaccio. A. R. Rana. R. A. Vannucchi. A. M. and Manzoli. F. A. et al.
Role of thrombopoietin in mast cell differentiation
Source/Expression System Recombinant
Category Protein
Unit 0.01 mg
Description Summary: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation. as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL. the product of myeloproliferative leukemia virus oncogene. Sequence Length (aa): 353 KEGG pathway: Hematopoietic cell lineage 04640 OMIM: NCBI [ 600044] Applications Tested: FN Cross-Reactivity: Human Storage: Prior to reconstitution store at +4C. Following reconstitution store at +4C or at -20C if preferred.This product should be stored undilutedStorage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature Stability: 3 months from date of reconstitution. Specificity: THROMBOPOIETIN Specificity: THROMBOPOIETIN Approx. Protein Conc: 0.5 mg/ml Endotoxin Level: