Human Interferon-gamma

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Target Tag/Conjugate Unconjugated
Species Human
Format Purity: >= 95% by SDS PAGE
Format: Liquid. In Phosphate Buffered Saline (PBS). pH 7.4.
Target/Molecule Synonym hIFN-gamma, IFN-gamma, Ifng, IFNG_RAT
Category Protein
Source/Expression System E. Coli
References [1] Dijkema.R. van der Meide.P.H. Dubbeld.M. Caspers.M. Wubben.J. and Schellekens.H.
Cloning. expression. and purification of rat IFN-gamma
[2] Dijkema R. van der Meide P.H. Pouwels P.H. Caspers M. Dubbeld M. Schellekens H.
Cloning and expression of the chromosomal immune interferon gene of the rat.
[3] Dijkema R. der Meide P.H. Dubbeld M. Caspers M. Wubben J. Schellekens H.
Cloning. expression. and purification of rat IFN-gamma.
[4] Widegren B. Visse E. Sjogren H.O.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
Applications SDS
Original Item Name Interferon-gamma human
Molecule Name Interferon-gamma
Unit 1 mg
Description Human interferon -gamma (hIFN-gamma) is secreted by lymphocytes stimulated by mitogen and is involved in the differentiation. maturation. and proliferation of hematopoietic cells. Nature human interferon-gamma is composed of 143amino acid residues without cysteine residues and is glycosylated. Recombinant human interferon -gamma was expressed in E.coli and purified by FPLC gel-filtration chromatography. after refolding of the isolated inclusion bodies in a renaturation buffer. Additional amino acid (Methionine) is attached at N-terminus.Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma. in addition to having antiviral activity. has important immunoregulatory functions. It is a potent activator of macrophages. it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.Subunit: Homodimer.Subcellular Location: Secreted protein.Tissue Specificity: Released primarily from activated T lymphocytes.Similarity: Belongs to the type II (or gamma) interferon family. Sequence Length (aa): 156 MW: 17918 Applications Tested: SDS Applications Not Tested: MS Testing Protocols: SDS: 14% SDS PAGE||10-002-38027_SDHuman Storage: Store at -20°C. Avoid frequent freeze and thaw. Stability: 6-12 months at -70°C. Product ID: 38027