Human D-3-phosphoglycerate dehydrogenase

  • Human D-3-phosphoglycerate dehydrogenase

    CatalogueID : GWB-B0CDE1

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Species Human
Target/Molecule Synonym 3-phosphoglycerate dehydrogenase, EC 1.1.1.95, 3-PGDH, PGDH3, PDG, PGD, PGAD, PGDH, SERA, 3PGDH, 3-PGDH, MGC3017
Format Purity: 0.95
Format: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3.
Target Tag/Conjugate Unconjugated
EC Number EC 1.1.1.95
Source/Expression System E. coli
Applications MS, SDS
Molecule Name D-3-phosphoglycerate dehydrogenase
References [1] Pande.H.. Campo.K.. Tanamachi.B. and Zaia.J.A.. et al.
Human cytomegalovirus strain Towne pp65 gene: nucleotide sequence and expression in Escherichia coli
[2] Pande H.. Campo K.. Tanamachi B.. Zaia J.A.
Human cytomegalovirus strain Towne pp65 gene: nucleotide sequence and expression in Escherichia coli.
[3] Pande H.. Lee T.D.. Churchill M.A.. Zaia J.A.
Structural analysis of a 64-kDa major structural protein of human cytomegalovirus (Towne): identification of a phosphorylation site and comparison to pp65 of HCMV (AD169).
Original Item Name D-3-phosphoglycerate dehydrogenase
Category Protein
Accession Number NCBI Accession Number: NP_006614.1
Swiss Protein Accession Number: O43175
Unit 0.05 mg
Description Catalytic Activity: 3-phosphoglycerate + NAD+ = 3-phosphonooxypyruvate + NADH.Pathway: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1.Subunit: Homotetramer (By similarity).Disease: Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:601815]. It is characterized by congenital microcephaly. psychomotor retardation. and seizures.Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Entry Name: SERA_HUMAN Chromosome Location: 1p12 Sequence Position 1: 1 Sequence Position 2: 533 Length (aa): 533 MW: 56519 OMIM: 601815; phenotype. [ NCBI / EBI]606879; gene. [ NCBI / EBI] Applications: MS. SDS Applications Not Tested: ELISA, Western Blot Testing Protocols: SDS: Analysis of PHGDH Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining.||10-288-22259F_SD Storage: -70°C. Avoid frequent freeze and thaw. Stability: 6-12 months at -70°C. Fusion: T7 tag at N-terminus.