Mouse Anti-E-Cadherin Monoclonal antibody, Unconjugated, Clone 4a2c7

  • Mouse Anti-E-Cadherin Monoclonal antibody, Unconjugated, Clone 4a2c7

    CatalogueID : 180223

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Target E-Cadherin
Clone Clone 4a2c7
Target Species Mus musculus
Unit 100 ug
Description This monoclonal antibody reacts with human epithelial cadherin (E-cadherin, uvomorulin, Cell-CAM 120/80), a 120 kDa transmembrane glycoprotein. Reduction and/or loss of E-cadherin expression in carcinomas correlates positively with tumor cell invasion and metastasis. Altered expression of E-cadherin is common in the progression of cancers including breast carcinoma, lung carcinoma, gastric tumors, hepatocellular carcinoma, and prostatic tumors. It has recently been reported that E-cadherin is a useful marker for differentiating lobular lesions (negative) from ductal invasive lesions (positive) in breast cancer. Positive tissue: Non-neural epithelia. Clone/PAD: 4A2C7 Immunogen: Recombinant protein corresponding to the cytoplasmic domain of human E-cadherin Specificity: Reacts strongly with human E-cadherin and weakly with human P-cadherin. Reactivity: Human Applications: Immunohistochemistry (FFPE) Pretreatment: Epitope Retrieval: Required (Citrate Buffer, pH 6), Enzyme Digestion: Not required Expected Staining Pattern: Mainly cellular membrane, some cytoplasmic
Clonality Monoclonal