Mouse Anti-Human Acetyl CoA Carboxylase 1 Monoclonal antibody, Unco...

  • Mouse Anti-Human Acetyl CoA Carboxylase 1 Monoclonal antibody, Unconjugated, Clone 143

    CatalogueID : 437100

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Target Acetyl CoA Carboxylase 1
Host Species Homo sapiens
Clone Clone 143
Target Species Mus musculus
Unit 0.5 ml
Description Acetyl CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA. In cells, excess of metabolic fuel is converted into fatty acids in cytosol and oxidized later in mitochondria to generate ATP and acetyl-CoA. The limiting step in fatty acid synthesis is the catalytic formation of malonyl-CoA (precursor for long-chain fatty acetyl-CoA, LCFA-CoA) from acetyl-CoA by a 256 kDa protein called Acetyl CoA carboxylase 1 (ACC-1).1 The translocation of LCFA-CoA from cytosol to mitochondria is catalyzed by two carnitine palmitoyl transferases (CPT-1 & CPT-2) and regulated by ACC-2, the rate limiting step of mitochondrial fatty acid oxidation. Activities of ACC-1 and 2 are regulated by their phosphorylation by 5’-AMP-activated protein kinase (AMPK).2 Diabetes deranges AMPK master-switch and represses the ACC-1 gene-expression and stimulates excessive fatty acid oxidation which in turn interferes with glucose metabolism.
Clonality Monoclonal