Mouse Anti-ISG15 Monoclonal antibody, Unconjugated, Clone 97

  • Mouse Anti-ISG15 Monoclonal antibody, Unconjugated, Clone 97

    CatalogueID : 433180

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Target ISG15
Clone Clone 97
Target Species Mus musculus
Unit 0.2 ml
Description Mouse anti-ISG15 (Sku 433180) detects human ISG15, and is validated in western blot application, with confirmed reactivity in human and Rat tissues. Reactivity against rhesus monkey and chimpanzee is also expected based on sequence homology. ISG15 (interferon-induced 17 kDa protein) is a ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Substrate specificity and interaction with ligating enzymes differs from that of ubiquitin. Conjugation of ISG15 uses E1 enzyme Ube1L, and the difference to ubiquitin pathway happens at the level of E2 enzyme. ISG15 conjugation system favors UbcH8 as its E2 enzyme. ISG15 has a large number of both IFN-induced and constitutively expressed proteins, such as STAT1, SERPINA3G, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. ISG15 is deconjugated by USP18/UBP43.
Clonality Monoclonal