Mouse Anti-MSH2 Monoclonal antibody, Unconjugated, Clone fe11

  • Mouse Anti-MSH2 Monoclonal antibody, Unconjugated, Clone fe11

    CatalogueID : 182343

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Target msh2
Clone Clone fe11
Target Species Mus musculus
Unit 100 ug
Description This monoclonal antibody reacts with human and mouse MSH2 (MutS homologue 2), a 100 kDa protein involved in mismatched nucleotides during DNA replication or repair process. It recognizes an epitope within the C-terminal region of the MSH2 protein. MSH2 functions as one of the four major DNA mismatch repair genes, along with MLH1, PMS2 and PMS1. Somatic mutations in the human MSH2 gene contribute to development of sporadic colorectal carcinomas, while germline mutations are involved in a large number of colorectal carcinomas. Positive tissue: Normal colon/breast cancer. Clone/PAD: FE11 Immunogen: C-terminal fragment of the human MSH2 protein Specificity: MSH2 Reactivity: Human, Mouse Applications: Immunohistochemistry (FFPE) Pretreatment: Epitope Retrieval: Required (EDTA, pH 8.0), Enzyme Digestion: Not Required Expected Staining Pattern: Predominantly nuclear with some cytoplasmic
Clonality Monoclonal