Mouse Anti-Multi-Drug Resistance 1 Monoclonal antibody, Unconjugate...

  • Mouse Anti-Multi-Drug Resistance 1 Monoclonal antibody, Unconjugated, Clone c494

    CatalogueID : 187243

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Target Multi-Drug Resistance 1
Clone Clone c494
Target Species Mus musculus
Unit 100 ug
Description This monoclonal antibody reacts with p-glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells with secretory and excretory functions and is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. Elevated levels of p-glycoprotein have been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias/lymphomas. Positive tissue: Liver/colon. Clone/PAD: C494 Immunogen: Multi-drug resistant CHO cells Specificity: Reacts with a gene-specific, internal cellular epitope present only on the MDR1 isoform of p-glycoprotein. Reactivity: Human Applications: Immunohistochemistry (FFPE) Pretreatment: Epitope Retrieval: Not required, Enzyme Digestion: Not required Expected Staining Pattern: Membrane
Clonality Monoclonal