Rabbit Anti-C-Met, phospho (Tyr1349) Polyclonal antibody, Unconjuga...

  • Rabbit Anti-C-Met, phospho (Tyr1349) Polyclonal antibody, Unconjugated, Clone pab (rb igg)

    CatalogueID : 44892G

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Target C-Met
Target Species Oryctolagus cuniculus
Unit 1.5 mg
Description Binding of scatter factor (SF)⁄hepatocyte growth factor (HGF) to the c-Met receptor tyrosine kinase (RTK) triggers receptor dimerization and phosphorylation on multiple residues within the juxtamembrane, catalytic core and cytoplasmic tail domains, thereby regulating receptor internalization, catalytic activity and multisubstrate docking. Activation of the c-Met⁄HGF receptor results in binding and⁄or phosphorylation of many intracellular signaling proteins including multiple adaptor proteins (e.g., Grb2, Shc, Cbl, Crk, cortactin, paxillin, and GAB1), and a variety of other signal transducers (e.g., PI 3-kinase, FAK, Src, ERK1&2, JNK1&2, PLC-γ, and STAT3).
Clonality Polyclonal
Protein Modification Phosphorlyated
Site of Protein Modification Tyr 1349