Rabbit Anti-Cul-2 Abfinityâ„¢ Monoclonal Antibody , Unconjugated

  • Rabbit Anti-Cul-2 Abfinityâ„¢ Monoclonal Antibody , Unconjugated

    CatalogueID : 700179

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Target CUL-2
Target Species Oryctolagus cuniculus
Unit 100 ul
Description ABfinityâ„¢ Recombinant Rabbit Monoclonal Antibody validated to Rat, Mouse, Human and expected reactivity with human, mouse, rat, primate, canine and numerous other species. This antibody is validated for use in Western Blot, Immunohistochemistry, Immunofluorescence, and Flow Cytometry. Cul-2 is encoded by the 8453 gene, also known as Cullin 2, MCG131970. In yeast, proteolysis of G1 cell cycle regulatory proteins is controlled by an ubiquitin ligase formed by three subunits: Cdc53 (also known as CulA), Skp1 and one of many F-box proteins (3). A family of human cullin genes homologous to the S. cerevisiae cdc53 gene has been identified (cul1, 2, 3, 4a, 4b, and 5) (1). In humans Cul2 is part of the ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex which contains the Cullin-RBX module (4). Human Cul2 does not associate with Skp1 and Skp2. Instead it forms a complex with an inactive transcriptional elongation complex, SIII, formed by three subunits: Elongin C, Elongin B and VHL(2).
Clonality Monoclonal