Lactacystin (native)

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Molecular Weight 376.4
Keywords CAR/ANG| CAR/ATU| CDA/BCD| IMM/IND| IMM/INI| INF/NFK| INF/TLR| NAT/AIA/ABA| NAT/CRR| NAT/CDR| NAT/SPM| PRT/PIS| PEM/STR/HSP| SIG/NFK| STR/HSP| NAT/PRU| DDI/SMM| PSS/DEG/UPS| PSS/SFU/UFP Proteasome| NF-kappaB| Cathepsin Inhibitor| Inhibitor| Inhibitor
Formula C15H24N2O7S
Brand/Trademark ALEXIS
CAS Number 133343-34-7
Specifications/Features

Mainfeature: Proteasome inhibitor

Purity ≥97% (HPLC)
Sample Type White to off-white powder.
Target/Molecule Synonym Proteasome 26S, NF-kappaB, Cathepsin A
Unit 1 mg
Description Cell permeable and irreversible proteasome inhibitor. Specifically inhibits 26S proteasome (MCP; multicatalytic proteinase complex). Blocks proteasome activity by targeting the catalytic β-subunit. Has no effect on serine or cysteine proteases. Induces apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation by inhibiting IκB degradation. Inhibits the ubiquitin proteasome pathway in cell culture (IC50=10µM). Inhibits cathepsin A. Upregulates HSP70 and HSP22, suggesting an initial neuroprotective pathway