Rocaglamide

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Purity ≥98% (HPLC)
Molecular Weight 505.6
Keywords Inhibitor CAR/CHP| CAR/CYT/ADK| CAR/CYT/TNF| CDA/BCD| CDA/TNF| DNA/BGE| DNA/TRR| END/CYT/ADK| END/CYT/TNF| IMM/AUI| IMM/BIR| IMM/CYT/ADK| IMM/CYT/TNF| IMM/INI| IMM/TCS| INF/NFK| INF/TLR| NAT/CRR| NAT/CDR| NAT/DNR| NAT/IMO| NAT/SPM| SIG/NFK| SIG/REP/TNF| DDI/SMM NF-kappaB
Brand/Trademark ALEXIS
Sample Type White to off-white sticky solid.
Item Name Synonyms Rocaglamide A
Target/Molecule Synonym NF-kappaB
Formula C29H31NO7
Specifications/Features

Mainfeature: NF-κB inhibitor

CAS Number 84573-16-0
Unit 100 µg
Description Immunosuppressant. Potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. In contrast to the immunosuppressant cyclosporin A (Prod. No. BML-A195), rocaglamide does not inhibit calcineurin phosphatase activity. Induces apoptosis