Rat IL-17AF Heterodimer

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Brand/Trademark Shenandoah Biotechnology
Accession Number Q61453/Q5BJ95
Applications BioAssay, In Vitro Stimulation, In Vivo Stimulation, ELISA Standard
Purity Typically ≥ 97, see website for details
Species Rat
Source/Expression System E.coli
Original Item Name Rat IL-17-AF
Molecule Name Recombinant rat Interleukin-17AF (IL-17AF heterodimer)
Type Protein
Gene Name interleukin 17F, similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8), similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8), interleukin 17F
Entrez GeneID 301291, 301291, 301289, 301289
Gene Symbol Il17f, LOC301289, LOC301289, Il17f
NCBI Gene Aliases MGC11440
Unit 100 ug
Description Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17RA receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant rat IL-17AF is a non-glycosylated, disulfide-linked heterodimer, comprised of one monomeric subunit of each, IL-17A and IL-17F. The dimer has a total of 271 amino acids, with total molecular weight of 30.7 kDa.