Human Interleukin-2 (C145S)

  • Human Interleukin-2 (C145S)

    CatalogueID : GWB-B9A583

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Target/Molecule Synonym IL-2, T-cell growth factor, TCGF, Aldesleukin, IL2, IL2_HUMAN
Format Purity: >= 95% by SDS PAGE
Format: Liquid. In Phosphate Buffered Saline (PBS). pH 7.4.
Species Human
Target Tag/Conjugate Unconjugated
Original Item Name Interleukin-2 (C145S) human
Applications SDS
References [1] Lupker.J. Miloux.B. and Roskam.W. et al.
Recombinant eukaryotic cells producing interleukin-2. method and vectors for obtaining them and method for obtaining interleukin-2
[2] Holbrook N.J. Lieber M. Crabtree G.R.
DNA sequence of the 5' flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus.
[3] Taniguchi T. Matsui H. Fujita T. Takaoka C. Kashima N. Yoshimoto R. Hamuro J.
Structure and expression of a cloned cDNA for human interleukin-2.
[4] Maeda S. Nishino N. Obaru K. Mita S. Nomiyama H. Shimada K. Fujimoto K. Teranishi T. Hirano T. Onoue K. et al.
Cloning of interleukin 2 mRNAs from human tonsils.
[5] Devos R. Plaetinck G. Cheroutre H. Simons G. Degrave W. Tavernier J. Remaut E. Fiers W.
Molecular cloning of human interleukin 2 cDNA and its expression in E. coli.
[6] Holbrook N.J. Smith K.A. Fornace A.J. Jr. Comeau C.M. Wiskocil R.L. Crabtree G.R.
T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells.
[7] Fujita T. Takaoka C. Matsui H. Taniguchi T.
Structure of the human interleukin 2 gene.
[8] Eizenberg O. Faber-Elman A. Lotan M. Schwartz M.
Interleukin-2 transcripts in human and rodent brains: possible expression by astrocytes.
[9] Chernicky C.L. Tan H. Burfeind P. Ilan J. Ilan J.
Sequence of interleukin-2 isolated from human placental poly A+ RNA: possible role in maintenance of fetal allograft.
[10] Rieder M.J. Carrington D.P. Chung M.-W. Lee K.L. Poel C.L. Yi Q. Nickerson D.A.
SeattleSNPs. NHLBI HL66682 program for genomic applications. UW-FHCRC. Seattle. WA (URL: http://pga.gs.washington.edu).
Source/Expression System E. Coli
Category Protein
Molecule Name Interleukin-2 (C145S)
Unit 0.05 mg
Description IL-2. also known as T cell growth factor (TCGF). is an immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells. NK cells. lymphokine activated killer cells. monocytes. macrophages and oligodendrocytes. This recombinant human IL-2 is a 15.4 kDa protein. containing 133 amino acid residues including one intra chain disulfide bond. Recombinant human IL-2 was overexpressed in E. coli and purified by conventional chromatography. after refolding of the isolated inclusion bodies in a renaturation buffer.Function: Produced by T-cells in response to antigenic or mitogenic stimulation. this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells. monocytes. lymphokine-activated killer cells. natural killer cells. and glioma cells.Subcellular Location: Secreted protein.Disease: A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.Pharmaceutical: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.Similarity: Belongs to the IL-2 family. Sequence Length (aa): 153 MW: 17628 OMIM: 147680; gene. [ NCBI / EBI] Applications Tested: SDS Applications Not Tested: MS Testing Protocols: SDS: 15% SDS PAGE||10-002-38032_SDHuman Storage: Store at -20°C. Avoid frequent freeze and thaw. Stability: 6-12 months at -70°C. Product ID: 38032