Mitogen-activated protein kinase 11

  • Mitogen-activated protein kinase 11

    CatalogueID : GWB-3DE5BA

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Target/Molecule Synonym EC 2.7.11.24, Mitogen-activated protein kinase p38 beta, MAP kinase p38 beta, p38b, p38-2, Stress-activated protein kinase 2, MAPK11, PRKM11, SAPK2, MK11_HUMAN
Target Tag/Conjugate Unconjugated
References [1] Husmann.M. Dersch.K. Bobkiewicz.W. Beckmann.E. Veerachato.G. and Bhakdi.S.
Differential role of p38 mitogen activated protein kinase for cellular recovery from attack by pore-forming S. aureus alpha-toxin or streptolysin O
[2] Tanos.T. Marinissen.M.J. Leskow.F.C. Hochbaum.D. Martinetto.H. Gutkind.J.S. and Coso.O.A.
Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light
[3] Canfield.S. Lee.Y. Schroder.A. and Rothman.P. et al.
Cutting edge: IL-4 induces suppressor of cytokine signaling-3 expression in B cells by a mechanism dependent on activation of p38 MAPK
[4] Casanovas.O. Jaumot.M. Paules.A.B. Agell.N. and Bachs.O. et al.
P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation
[5] Shin.J. Park.B. Cho.S. Lee.S. Kim.Y. Lee.S.O. Cho.K. Lee.S. Jin.B.S. Ahn.J.H. Choi.E.J. and Ahn.K.
Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase
[6] Jiang Y. Chen C. Li Z. Guo W. Gegner J.A. Lin S. Han J.
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).
[7] Jiang Y. Han J.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
[8] Kumar S. McDonnell P.C. Gum R.J. Hand A.T. Lee J.C. Young P.R.
Novel homologues of CSBP/p38 MAP kinase: activation. substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.
[9] Enslen H. Raingeaud J. Davis R.J.
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.
[10] Goedert M. Cuenda A. Craxton M. Jakes R. Cohen P.
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
Molecule Name Mitogen-activated protein kinase 11
Category Protein
Source/Expression System Insect Cells
EC Number EC 2.7.11.24
Original Item Name Mitogen-activated protein kinase 11
Unit 0.001 mg
Description Recombinant full-length human p38beta was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.Function: Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. by cytokines. or by environmental stress. Phosphorylates preferentially transcription factor ATF2.Catalytic Activity: ATP + a protein = ADP + a phosphoprotein.Cofactor: Magnesium (By similarity).Enzyme Regulation: Activated by phosphorylation on threonine and tyrosine by MKK6. Inhibited by pyridinyl-imidazole related compounds.Tissue Specificity: Highest levels in the brain and heart. Also expressed in the placenta. lung. liver. skeletal muscle. kidney and pancreas.Similarity: Belongs to the Ser/Thr protein kinase family. MAP kinase subfamily.Similarity: Contains 1 protein kinase domain.Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals. and are involved in a wide variety of cellular processes such as proliferation. differentiation. transcription regulation. and development. This kinase is most closely related to p38 MAP kinase. both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs). preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. Sequence Length (aa): 364 MW: 42132KEGG pathway: Epithelial cell signaling in Helicobacter pylori infection 05120KEGG pathway: Fc epsilon RI signaling pathway 04664KEGG pathway: GnRH signaling pathway 04912KEGG pathway: Leukocyte transendothelial migration 04670KEGG pathway: MAPK signaling pathway 04010KEGG pathway: Toll-like receptor signaling pathway 04620KEGG pathway: VEGF signaling pathway 04370 OMIM: 602898; gene. [ NCBI / EBI] Testing Protocols: Specific Activity: ||10-782-55057_1!!Purity: ||10-782-55057_2 Cross-Reactivity: Storage: Store product at -70°C. For optimal storage. aliquot target into smaller quantities after centrifugation and store at recommended temperature. Stability: 1 year at -20°C. Product ID: 55057