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Format Purity: Immuno-affinity chromatography. Purification is verified by SDS-PAGE. Other antigens are not detected with ELISA assays.
Format: Affinity Purified, Liquid
Target Tag/Conjugate Unconjugated
Target/Molecule Synonym SS-A (Ro) Antigen, 60 kDa ribonucleoprotein Ro, RoRNP, 60 kDa Ro protein, Ro 60 kDa autoantigen, TROVE domain family member 2, Sjoegren syndrome type A antigen, SS-A, Sjoegren syndrome antigen A2, RO60, SSA2
Original Item Name SS-A (Ro) Antigen
Category Native Protein
Molecule Name TROVE2
Source/Expression System Calf Spleen, Bovine materials are of US origin.
Unit 1000 Units
Description Background: SS-A (RO) AntigenFunction: RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation.Subunit: Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.Subcellular Location: Cytoplasm.Ptm: Phosphorylated upon DNA damage, probably by ATM or ATR.Disease: Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign.Similarity: Belongs to the Ro 60 kDa family.Similarity: Contains 1 TROVE domain.products ID: 248356Accession Number: NP_001035828.1Sp Accession Number: P10155OMIM: 600063Molecular Weight: 60671NCBI Name: 60 kDa SS-A/Ro ribonucleoproteinInteraction: Q9UHX1, EBI-1049168, EBI-1053259Storage: Upon receipt, store at -70 C. Aliquot to avoid multiple freeze/thaw cycles.Specificity: SS-A (Ro) AntigenType of Product: Purified Autoimmune ReagentsConcentration: Lot specificInactivation: Not applicablePreservatives: 0.02% Sodium azideBuffer: 0.01M Tris, 0.53M Sodium chlorideApplications Notes : Recommended for use in standard solid phase immunoassays. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1–1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.