Human IL13RA1

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Target/Molecule Synonym Human CA19-9 Antigen Grade, IL-13R-alpha-1, IL-13RA-1, Cancer/testis antigen 19, CT19, CD213a1 antigen, IL13R, IL13RA
Target Tag/Conjugate Unconjugated
Species Human
Format Purity: Gel filtration and column chromatography
Format: Purified, Liquid
Applications ELISA
Source/Expression System Human
Molecule Name IL13RA1
Category Native Protein
Original Item Name Human CA19-9 Antigen Grade
Unit 250000 Unit
Description Background: Human CA19-9 Antigen Grade. Human Cancer Antigen 19-9 (CA19-9) (Gastrointestinal Cancer) Antigen GradeFunction: Binds IL13 with a low affinity. Together with IL4R-alpha can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling, but cannot replace the function of gamma C in allowing enhanced IL2 binding activity.Subunit: Interleukin 13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.Subcellular Location: Membrane; Single-pass type I membrane protein.Tissue Specificity: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.Domain: The box 1 motif is required for JAK interaction and/or activation.Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily.products ID: 248808Accession Number: NP_001551.1Sp Accession Number: P78552OMIM: 300119Molecular Weight: 48760NCBI Name: Interleukin-13 receptor alpha-1 chainInteraction: P35225, EBI-1391535, EBI-1647828, Q6PCT1, EBI-1391535, EBI-1104484Storage: Upon receipt, store at -20 C.Specificity: Cancer Antigen CA19-9 (Gastrointestinal Cancer) Antigen GradeType of Product: Purified Reagents for Cancer ResearchConcentration: 330KU/mlInactivation: Not applicablePreservatives: NaN3Buffer: PBS, pH 7.4 containing 3% sucroseApplications Notes : Immunogen, calibrator in immunoassays and in vitro studies. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1–1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.