Human IL1A

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Target Tag/Conjugate Unconjugated
Format Purity: >95% by SDS-PAGE
Format: Liquid
Target/Molecule Synonym IL-1A, IL-1a, IL1-alpha, IL1F1, hematopoietin-1, interleukin 1 alpha., IL-1 alpha, Hematopoietin-1, IL1F1
Species Human
Source/Expression System Recombinant, E. coli
Category Protein
Original Item Name Interleukin 1 alpha: Human, Recombinant, E Coli
References 1: Dinarello, C.A. (2002) Clin. Exp. Rheumatol. 20(5 s.27):S1-13.
Applications SDS-Page
Molecule Name IL1A
Unit 0.1 mg
Description Background: Interleukin 1a is a proinflammatory cytokine produced by a wide variety of cell types, including macrophages, osteoblasts, monocytes and hepatocytes. Circulatinglevels of are normally low and only rise after stimulation by agents such as those produced by inflammation, infection or microbial endotoxins. IL-1 a possesses awide variety of biological activities and exerts its effects by binding to specific cell surface receptors..RANDOX recombinant IL-1a-chain comprises a 159amino acid fragment (113-271) corresponding to the mature IL-1a chain and is expressed in E. coli with anamino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic ortherapeutic use.Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.Subunit: Monomer.Subcellular Location: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.Similarity: Belongs to the IL-1 family.products ID: 288261Accession Number: NP_000566.3Sp Accession Number: P01583OMIM: 147760Molecular Weight: 30607NCBI Name: Interleukin-1 alphaInteraction: P29466, EBI-1749782, EBI-516667Pathways: KEGG pathway: Apoptosis KEGG pathway: Cytokine-cytokine receptor interaction KEGG pathway: Hematopoietic cell lineage KEGG pathway: MAPK signaling pathway KEGG pathway: Type I diabetes mellitus Testing Protocols: Test :10-731-288261_pi