MPO

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Target Tag/Conjugate Unconjugated
Format Purity: >98% pure (SDS-PAGE). Ion exchange and gel diffusion chromatography
Format: Purified, Lyophilized
Target/Molecule Synonym Myeloperoxidase, MPO, EC 1.11.1.7
Source/Expression System Human
Molecule Name MPO
Original Item Name Myeloperoxidase
Category Native Protein
Unit 1 mg
Description Background: Myeloperoxidase. Myeloperoxidase (MPO). . Molecular weight 59kDa (SDS-PAGE) indicating 2 protein subunits. Molecular weight 129kDa (S-200 chromatography)Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.Catalytic Activity: Donor + H2O2 = oxidized donor + 2 H2O.Catalytic Activity: Cl- + H2O2 = HOCl + 2 H2O.Cofactor: Binds 1 calcium ion per heterodimer.Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.Subunit: Tetramer of two light chains and two heavy chains.Subcellular Location: Lysosome.Disease: Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.Similarity: Belongs to the peroxidase family. XPO subfamily.products ID: 248420Accession Number: NP_000241.1Sp Accession Number: P05164OMIM: 254600, 606989Molecular Weight: 83869NCBI Name: MyeloperoxidasePathways: KEGG pathway: Coumarine and phenylpropanoid biosynthesis KEGG pathway: Methane metabolism KEGG pathway: Phenylalanine metabolism Storage: Store lyophilized product at 2-8 C. After reconstitution, store at 2-8 C.Specificity: MyeloperoxidaseType of Product: Purified Cardiac MarkersInactivation: Not applicableBuffer: Not applicable, Salt-freeApplications Notes : Specific methodologies have not been tested using this product.Concentration: Concentration is lot specific