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Purity ≥95% (HPLC)
Molecular Weight 1038.2
CAS Number 111755-37-4
Formula C49H75N13O12

Appearance: Clear to whitish film adhered to inside of vial.

Mainfeature: PP2A inhibitor

Identity: Identity determined by MS.

Background / Technical Information: Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.

Keywords Serine/threonine-protein phosphatase Inhibitor Microcystin-RR CAR/CAT| DYE/NOO| NAT/NMA| NAT/SPM| NAT/TOX| OXI/OXD| SIG/PHO| DDI/SMM| PSS/SFU/OXR
Brand/Trademark ALEXIS
Unit 500 µg
Description Arg-Arg analog of microcystin-LR (Prod. No. ALX-350-012). Hepatotoxic, although found to be up to 10-fold less toxic than microcystin-LR on i.p. injection in mice. Potent inhibitor of protein phosphatase 2A (PP2A)